English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/95527
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
 |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

Autor Rigos, George; Zonaras, V.; Nikoloudaki, X.; Cotou, E.; Henry, M.; Varó, Inmaculada ; Alexis, M.
Palabras clave Plant oil
Gilthead sea bream
Fecha de publicación 2013
EditorHellenic Centre for Marine Research
Citación Mediterranean Marine Science 14(2): 377-383 (2013)
ResumenThe distribution and depletion profile of sulfadiazine (SDZ) were investigated in gilthead sea bream (Sparus aurata) fed on fish oil (FO) or plant oil-based (PO) diets. Fish averaging 230 g were given medicated feed containing 25 mg SDZ kg-1 fish for 5 days at 24-26°C. Blood and muscle plus skin were sampled on days 1, 3, 5, 6, 8 and 9. Differences in plasma and fillet SDZ levels between the two groups were statistically insignificant. The maximum drug concentrations in plasma were 3.2 ± 1.9 μg mL-1 and 2.9 ± 1.2 μg mL-1 in the PO and FO groups, respectively. In post-medicated samples depletion rapidly reached concentrations close to the level of quantification at 72 h post medication. Withdrawal times to reach consumer safety levels were calculated to be 103 and 118 h for the FO and the PO groups, respectively. N4-acetylation was found to be the major metabolic pathway of SDZ in gilthead sea bream fillet accounting for 23 and 19% of the parent compound in the FO and the PO groups, respectively. Overall, alteration of the dietary lipid profile induced insignificant effects on the kinetics of SDZ. The high tissue SDZ levels during medication and the fast removal of the parent compound and its metabolites from edible tissues of gilthead sea bream reflect a promising antibacterial profile.
URI http://hdl.handle.net/10261/95527
Identificadoresdoi: 10.12681/mms.490
issn: 1108-393X
Aparece en las colecciones: (IATS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
distribucion_depletion_sulfadiazine.pdf434,81 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.