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Title

RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions

AuthorsCruz-Gallardo, Isabel CSIC ORCID; Aroca, Ángeles CSIC ORCID; Persson, Cecilia; Karlsson, B. Göran; Díaz-Moreno, Irene CSIC ORCID
KeywordsDNA/RNA binding protein (D/RBP)
pH-dependence
NMR
RNA recognition motif (RRM)
T-cell intracellular antigen-1 (TIA-1)
Issue Date2013
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry, (2013)
AbstractBackground: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding of TIA-1 RRM3 domain (isolated or fused to RRM2) to RNA is affected by pH changes. Conclusion: The pH-dependence of RRM3/RNA interaction may have a significant effect in the overall TIA-1 function. Significance: Unveiling the auxiliary role of RRM3 in RNA recognition sheds light on the TIA-1 function between cell compartments changes due to the protonation / deprotonation of TIA-1 RRM3 histidine residues. The auxiliary role of the Cterminal RRM3 domain in TIA-1 RNA recognition is poorly understood and this work provides an insight into its binding mechanisms
Publisher version (URL)http://dx.doi.org/10.1074/jbc.M113.489070
URIhttp://hdl.handle.net/10261/95466
DOIhttp://dx.doi.org/10.1074/jbc.M113.489070
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