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Cruz-Gallardo, I., Díaz-Moreno, I., Díaz-Quintana, A., Donaire, A., Velázquez-Campoy, A., Curd, R. D., … De la Rosa, M. A. (2013, July). Antimalarial Activity of Cupredoxins. Journal of Biological Chemistry. Elsevier BV. http://doi.org/10.1074/jbc.m113.460162 |
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| Título: | Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin |
Autor: | Cruz-Gallardo, Isabel CSIC ORCID; Díaz-Moreno, Irene CSIC ORCID; Díaz-Quintana, Antonio; Velázquez-Campoy, Adrián; Curd, Rachel D.; Rangachari, Caveri; Bridsall, Berry; Ramos, Andrés; Holder, Anthony A.; Rosa, Miguel A. de la | Palabras clave: | Malaria Plamodium MSP1 Rustycianin NMR ITC |
Fecha de publicación: | 2013 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | Journal of Biological chemistry, (2013) | Resumen: | Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugs | Versión del editor: | http://dx.doi.org/10.1074/jbc.M113.460162 | URI: | http://hdl.handle.net/10261/95459 | DOI: | 10.1074/jbc.M113.460162 |
| Aparece en las colecciones: | (IBVF) Artículos |
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| J. Biol. Chem.-2013-Cruz-Gallardo-jbc.M113.460162.pdf | 2,89 MB | Adobe PDF |  Visualizar/Abrir |
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