English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/9533
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 5 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)

Fungal growth inhibitory properties of new phytosphingolipid analogues

Autor Mormeneo, David; Manresa, Ángeles; Casas Brugulat, Josefina; Llebaria, Amadeu; Delgado, Antonio
Palabras clave Analogues
Fecha de publicación 15-nov-2007
EditorSociety for Applied Microbiology
Blackwell Publishing
Citación Journal of Applied Microbiology 104(4): 1075-1081 (2007)
Resumen[Aims] To study the growth inhibitory properties of a series of phytosphingosine (PHS) and phytoceramide (PHC) analogues.
[Methods and Results] A panel of two yeast (Candida albicans and Saccharomyces cerevisiae) and six moulds (Aspergillus repens, Aspergillus niger, Penicillium chrysogenum, Cladosporium cladosporioides, Arthroderma uncinatum and Penicillium funiculosum) has been used in this study. A series of new PHS and PHC analogues differing at the sphingoid backbone and the functional group at C1 position were synthesized.
[Conclusions] Among PHS analogues, 1-azido derivative 1c, bearing the natural d-ribo stereochemistry, showed a promising growth inhibitory profile. Among PHC analogues, compound 12, with a bulky N-pivaloyl group and a Z double bond at C3 position of the sphingoid chain, was the most active growth inhibitor. Minimal inhibitory concentration values were in the range of 23–48 μmol l-1 for 1c and 44–87 μmol l-1 for 12.
[Significance and Impact of the Study] Only scattered data on the antifungal activity of phytosphingolipids have been reported in the literature. This is the first time that a series of analogues of this kind are tested and compared to discern their structural requirements for antifungal activity.
Descripción 7 pages, 5 figures.-- PMID: 18005346 [PubMed]
Versión del editorhttp://dx.doi.org/10.1111/j.1365-2672.2007.03635.x
URI http://hdl.handle.net/10261/9533
ISSN1365-2672 (Online)
1364-5072 (Print)
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Mormeneo_et_el_JApplMicrobiol_104_1075_2007.pdf343,23 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.