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Cellular Senescence as a Barrier to Environmental Carcinogenesis

Autor Vergel, Mar; Carnero, Amancio
Palabras clave Cellular senescence
Environmental carcinogenesis
Fecha de publicación 19-ene-2014
EditorOMICS Publishing Group
Citación Journal of Carcinogenesis and Mutagenesis S3: 004 (2014)
ResumenThe first cellular response to a carcinogen is a cell cycle arrest program that may end in a permanent arrest with features of cellular senescence. This may be an evolutionary conserved response to delay environmental-induced cancer until the replicative life of the organism has ended. With the concomitant alteration of genes involved in cellular senescence, which promotes cellular immortalization, a further carcinogenic insult may increase the chances of tumorigenesis and the development of a malignant clone. Therefore, understanding cellular senescence and how it can be modified by environmental carcinogens, including food, may be essential for controlling the increase of cancer prevalence.
Descripción This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI http://hdl.handle.net/10261/95212
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