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Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues

AuthorsMormeneo, David; Casas, Josefina ; Llebaria, Amadeu ; Delgado Cirilo, Antonio
KeywordsAntifungal evaluation
Phytosphingolipid analogues
Growth inhibitors
Yeast Saccaromyces cerevisiae
Issue Date8-Oct-2007
PublisherRoyal Society of Chemistry (UK)
CitationOrganic & Biomolecular Chemistry 5(23): 3769-3777 (2007)
AbstractA library of 64 phytosphingolipid analogues resulting from the systematic variation of the C1, C3, C4, and the N-acyl moiety of phytosphingosine (PHS) has been prepared from common scaffolds derived from the chiral pool and Sharpless asymmetric dihydroxylation reactions. Library members have been evaluated as growth inhibitors of the yeast Saccaromyces cerevisiae. In addition, 1-amino-N-pivaloyl PHS analogues were also tested as IPC synthase inhibitors, in comparison with the natural product khafrefungin.
Description9 pages, 4 figures.-- PMID: 18004456 [PubMed].
Publisher version (URL)http://dx.doi.org/10.1039/b709421c
Appears in Collections:(IQAC) Artículos
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