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Title

Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism

AuthorsRamos, Sonia ; Goya, Luis ; Álvarez, Carmen; Martín, M. Ángeles ; Agote, María; Escrivá, Fernando; Pascual-Leone, Ana María
Issue Date2001
PublisherAmerican Physiological Society
CitationA J P - Endocrinology and Metabolism 281(5): E1073-E1081 (2001)
AbstractTwo groups of hypothyroid rats were used; one group was given 2-mercapto-1-methylimidazole (MMI) treatment in the drinking water of the mothers and was killed at 2 and 4 days of life, and the other group was given similar MMI treatment and then was thyroidectomized at 5 days of life and killed at 8 or 20 days. Serum insulin, growth hormone (GH), and insulin-like growth factor I (IGF-I) were decreased in MMI-treated rats but increased in MMI-treated plus thyroidectomized rats. No significant reduction of thyroid hormones was observed in 2-day-old MMI rats. Protein and mRNA expression of GLUT-1 increased, and those of GLUT-4 decreased, in the heart in all populations independent of changes in insulin, GH, and IGF-I levels. However, GLUT-4 protein and mRNA expression in quadriceps and gastrocnemius skeletal muscles decreased at 4 days and increased at 8 and 20 days of life in parallel with insulin, GH, and IGF-I levels. GLUT-1 in the skeletal muscles seemed regulated posttranscriptionally and presented a decrease of mRNA expression in all stages studied. A differential sensitivity to insulin regulation of GLUT-1 and GLUT-4 glucose transporters seems to be one of the causes for the tissue-specific regulation of these glucose transporters in heart and skeletal muscles during the perinatal period.
Publisher version (URL)https://doi.org/10.1152/ajpendo.2001.281.5.E1073
URIhttp://hdl.handle.net/10261/94956
DOI10.1152/ajpendo.2001.281.5.E1073
Identifiersissn: 0193-1849
Appears in Collections:(IF) Artículos
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