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Insecticidal and Mutagenic evaluation of two annonaceous acetogenins

AuthorsGuadaño, Ana; Gutiérrez, Carmen ; Peña de Torres, Eduardo de la ; Cortes, D; González-Coloma, Azucena
KeywordsInsecticidal evaluation
Mutagenic evaluation
Annonaceous acetogenins
Issue Date2000
PublisherAmerican Chemical Society
American Society of Pharmacognosy
CitationJournal of Natural Products, 63(6): 773-776 (2000)
AbstractAnnonaceous acetogenins represent a new class of bioactive compounds whose primary mode of action is the inhibition of NADH−ubiquinone oxidoreductase. Given the potential pesticidal use of such a class of compounds, we have further evaluated the antifeedant and insecticidal effects of squamocin and annonacin, two annonaceous acetogenins, on Spodoptera littoralis, Leptinotarsa decemlineata, and Myzus persicae. Additionally, to partially assess their environmental risk, we have also tested their mutagenicity in Salmonella typhimurium strains TA98, TA100, and TA102 in the presence and absence of a metabolic activation system. Among the test compounds, annonacin showed antifeedant effects on L. decemlineata, while squamocin was toxic to L. decemlineata and M. persicae. Neither acetogenin was mutagenic, although both were toxic in the absence of a metabolic activation system. We compared these results with those obtained with rotenone, a well-known respiratory inhibitor that was highly toxic to L. decemlineata and M. persicae and showed no mutagenicity/toxicity in the S. typhimurium strains tested up to a concentration of 1000 μg per plate.
Description3 páginas, 1 figura y 2 tablas estadísticas
Publisher version (URL)http://dx.doi.org/10.1021/np990328
Appears in Collections:(ICA) Artículos
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