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Título

Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery

Autor Vila, M.; Sánchez-Marcos, J. ; Prieto, C. ; Vallet-Regí, María
Palabras clave Carbon nanotubes
Cell stimulation
Drug delivery
Mesoporous silica
Fecha de publicación 2013
EditorJohn Wiley & Sons
Citación Journal of Biomedical Materials Research Part A 101A(1): 213-221 (2013)
ResumenThe development of smart materials as bone implants is nowadays a challenging task to optimize their fast osteointegration. Nevertheless, no attempts have been done in joining the possibility of using electrical stimulation and drug delivery together in a material intended for bone tissue engineering. Moreover, the use of this synergy to induce bone healing is still limited until novel drug reservoirs material formulations allow an efficient applicability of the electrical stimuli. Herein, we present the biological response of osteoblasts cells, cultured over carbon nanotubes-mesoporous silica composites while exposed to external electrical stimulus. Moreover, its ability to function as drug delivery systems is also demonstrated. Bone cell metabolism was stimulated and mitochondrial activity was increased up to seven times in the presence of these composites under electrical stimulus, suggesting their potential application in bone regeneration processes. © 2012 Wiley Periodicals, Inc.
URI http://hdl.handle.net/10261/94215
DOI10.1002/jbm.a.34325
10.1002/jbm.a.34325
Identificadoresdoi: 10.1002/jbm.a.34325
issn: 1549-3296
e-issn: 1552-4965
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