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Epistasis correlates to genomic complexity

AuthorsSanjuán, Rafael ; Elena, Santiago F.
Issue Date18-Sep-2006
PublisherNational Academy of Sciences (U.S.)
CitationProc. Natl. Acad. Sci. USA 103(39): 14402-14405 (2006)
AbstractWhether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations. We have collected data from widely different organisms and quantified epistasis in a common, per-generation scale. Simpler genomes, such as those of RNA viruses, display antagonistic epistasis (mutations have smaller effects together than expected); bacterial microorganisms do not apparently deviate from independent effects, whereas in multicellular eukaryotes, a transition toward synergistic epistasis occurs (mutations have larger effects together than expected). We propose that antagonistic epistasis might be a property of compact genomes with few nonpleiotropic biological functions, whereas in complex genomes, synergism might emerge from mutational robustness.
Description4 pages, 2 figures.-- Additional information (Suppl. Table S2: Synopsis of the studies seeking for epistasis between deleterious mutations, and Suppl. text: Possible factors that could have led to an artefactual correlation between epistasis and genome complexity) available at: http://www.pnas.org/content/103/39/14402/suppl/DC1
Publisher version (URL)http://dx.doi.org/10.1073/pnas.0604543103
Appears in Collections:(IBMCP) Artículos
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