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Título

Distributions of epistasis in microbes fit predictions from a fitness landscape model

Autor Martin, Guillaume; Elena, Santiago F. ; Lenormand, Thomas
Palabras clave Epistasis
Epistatic interactions
Multilocus genetics
Gene interactions
Evolutionary predictions
Simple fitness landscape model
Escherichia coli
Empirical data
Fecha de publicación 18-mar-2007
EditorNature Publishing Group
Citación Nature Genetics 39: 555-560 (2007)
ResumenHow do the fitness effects of several mutations combine? Despite its simplicity, this question is central to the understanding of multilocus evolution. Epistasis (the interaction between alleles at different loci), especially epistasis for fitness traits such as reproduction and survival, influences evolutionary predictions "almost whenever multilocus genetics matters". Yet very few models have sought to predict epistasis, and none has been empirically tested. Here we show that the distribution of epistasis can be predicted from the distribution of single mutation effects, based on a simple fitness landscape model. We show that this prediction closely matches the empirical measures of epistasis that have been obtained for Escherichia coli and the RNA virus vesicular stomatitis virus. Our results suggest that a simple fitness landscape model may be sufficient to quantitatively capture the complex nature of gene interactions. This model may offer a simple and widely applicable alternative to complex metabolic network models, in particular for making evolutionary predictions.
Descripción 6 pages, 4 figures.-- Supplementary information (Figures S1-S3, Table S1, Suppl. methods and Suppl. note) available at: http://www.nature.com/ng/journal/v39/n4/suppinfo/ng1998_S1.html
Versión del editorhttp://dx.doi.org/10.1038/ng1998
URI http://hdl.handle.net/10261/9410
DOI10.1038/ng1998
ISSN1061-4036
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