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Overlapping transcription and bacterial RNA removal

AuthorsLasa, Íñigo ; Villanueva, Maite
Issue Date25-Feb-2014
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences 111(8): 2868–2869 (2014)
AbstractThe precise understanding of the biology of a living cell requires the identification and quantification of the molecular components necessary to sustain life. One such element is RNA. Two independent high-throughput strategies are available to identify the entire collection of RNA molecules produced by a cell population, which is currently known as the transcriptome. One technique relies on microarray technology (tiling arrays), whereas the second one relies on sequencing the RNA pool (RNA-seq) (1). Both techniques offer the advantage that the identification of the RNA content is not biased by protein-based genome annotation. The application of these methods to the transcriptome analysis in bacteria has uncovered the existence of a large amount of RNA molecules that overlap at least in some portion with protein-encoding RNA transcripts, generating perfect sense/antisense RNA duplexes (2⇓⇓–5).
Publisher version (URL)http://dx.doi.org/10.1073/pnas.1324236111
Appears in Collections:(IDAB) Artículos
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