English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/9409
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 18 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)

Simple quasispecies models for the survival-of-the-flattest effect: The role of space

Autor Sardanyés, Josep ; Elena, Santiago F. ; Elena, Santiago F. ; Solé, Ricard V.
Palabras clave Survival-of-the-flattest
Quasispecies spatial dynamics
Virus evolution
Critical phenomena
Absorbing first-order phase transitions
Fecha de publicación 7-feb-2008
Citación Journal of Theoretical Biology 250(3): 560-568 (2008)
ResumenThe survival-of-the-flattest effect postulates that under high mutation rates natural selection does not necessarily favor the faster replicators. Under such conditions, genotypes which are robust against deleterious mutational effects may be favored instead, even at the cost of a slower replication. This tantalizing hypothesis has been recently proved using digital organisms, subviral RNA plant pathogens (viroids), and an animal RNA virus. In this work we study a simple theoretical system composed by two competing quasispecies which are located at two widely different fitness landscapes that represent, respectively, a fit and a flat quasispecies. The fit quasispecies is characterized by high replication rate and low mutational robustness, whereas the flat quasispecies is characterized by low replication rate but high mutational robustness. By using a mean field model, in silico simulations with digital replicons and a two-dimensional spatial model given by a stochastic cellular automata (CA), we predict the presence of an absorbing first-order phase transition with critical slowing down between selection for replication speed and selection for mutational robustness, where the surpassing of a critical mutation rate involves the outcompetition of the fit quasispecies by the flat one. Furthermore, it is shown that space, which involves a lower critical mutation rate, broadens the conditions at which the survival-of-the-flattest may occur.
Descripción 9 pages, 7 figures.
Versión del editorhttp://dx.doi.org/10.1016/j.jtbi.2007.10.027
URI http://hdl.handle.net/10261/9409
Aparece en las colecciones: (IBMCP) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.