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Title

Deep eutectic solvent-assisted synthesis of biodegradable polyesters with antibacterial properties

AuthorsGarcía-Argüelles, Sara ; Serrano, María C. ; Gutiérrez, María C. ; Ferrer, M. Luisa ; Yuste, Luis; Rojo, Fernando; Monte, Francisco del
Issue Date2013
PublisherAmerican Chemical Society
CitationLangmuir 29(30): 9525-9534 (2013)
AbstractBacterial infection related to the implantation of medical devices represents a serious clinical complication, with dramatic consequences for many patients. In past decades, numerous attempts have been made to develop materials with antibacterial and/or antifouling properties by the incorporation of antibiotic and/or antiseptic compounds. In this context, deep eutectic solvents (DESs) are acquiring increasing interest not only as efficient carriers of active principle ingredients (APIs) but also as assistant platforms for the synthesis of a wide repertoire of polymer-related materials. Herein, we have successfully prepared biodegradable poly(octanediol-co-citrate) polyesters with acquired antibacterial properties by the DES-assisted incorporation of quaternary ammonium or phosphonium salts into the polymer network. In the resulting polymers, the presence of these salts (i.e., choline chloride, tetraethylammonium bromide, hexadecyltrimethylammonium bromide, and methyltriphenylphosphonium bromide) inhibits bacterial growth in the early postimplantation steps, as tested in cultures of Escherichia coli on solid agar plates. Later, positive polymer cytocompatibility is expected to support cell colonization, as anticipated from in vitro preliminary studies with L929 fibroblasts. Finally, the attractive elastic properties of these polyesters permit matching those of soft tissues such as skin. For all of these reasons, we envisage the utility of some of these antibacterial, biocompatible, and biodegradable polyesters as potential candidates for the preparation of antimicrobial wound dressings. These results further emphasize the enormous versatility of DES-assisted synthesis for the incorporation, in the synthesis step, of a wide palette of APIs into polymeric networks suitable for biomedical applications. © 2013 American Chemical Society.
URIhttp://hdl.handle.net/10261/94029
DOI10.1021/la401353r
Identifiersdoi: 10.1021/la401353r
issn: 0743-7463
e-issn: 1520-5827
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