English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/9402
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 17 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

The effect of genetic robustness on evolvability in digital organisms

AutorElena, Santiago F. ; Sanjuán, Rafael
Palabras claveBiological systems
Genetic robustness
Evolvability
Adaptive evolutionary innovations
Avida digital evolution platform
Digital organisms
Time-dependence
Fecha de publicación14-oct-2008
EditorBioMed Central
CitaciónBMC Evolutionary Biology 2008, 8:284
Resumen[Background] Recent work has revealed that many biological systems keep functioning in the face of mutations and therefore can be considered genetically robust. However, several issues related to robustness remain poorly understood, such as its implications for evolvability (the ability to produce adaptive evolutionary innovations).
[Results] Here, we use the Avida digital evolution platform to explore the effects of genetic robustness on evolvability. First, we obtained digital organisms with varying levels of robustness by evolving them under combinations of mutation rates and population sizes previously shown to select for different levels of robustness. Then, we assessed the ability of these organisms to adapt to novel environments in a variety of experimental conditions. The data consistently support that, for simple environments, genetic robustness fosters long-term evolvability, whereas, in the shortterm, robustness is not beneficial for evolvability but may even be a counterproductive trait. For more complex environments, however, results are less conclusive.
[Conclusion] The finding that the effect of robustness on evolvability is time-dependent is compatible with previous results obtained using RNA folding algorithms and transcriptional regulation models. A likely scenario is that, in the short-term, genetic robustness hampers evolvability because it reduces the intensity of selection, but that, in the long-term, relaxed selection facilitates the accumulation of genetic diversity and thus, promotes evolutionary innovation.
Descripción9 pages, 3 figures.-- PMID: 18854018 [PubMed].-- PMCID: PMC2588588.
Versión del editorhttp://dx.doi.org/10.1186/1471-2148-8-284
URIhttp://hdl.handle.net/10261/9402
DOI10.1186/1471-2148-8-284
ISSN1471-2148
Aparece en las colecciones: (IBMCP) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Effect_genetic_robustness.pdf398,62 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.