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Title

Genotoxicity of the insecticide rotenone in cultured human lymphocytes

AuthorsGuadaño, Ana; González-Coloma, Azucena ; Peña de Torres, Eduardo de la
KeywordsGenotoxicity
Micronucleus
Rotenone
Lymphocyte
Natural insecticide
Issue Date1998
PublisherElsevier
CitationMutation Research 414: 1–7 (1998)
AbstractWe have investigated the genotoxic activity of rotenone on three genetic endpoints, sister-chromatid exchanges (SCE), chromosome aberrations (CA)and micronuclei (MN) in human lymphocyte cultures in the presence and absence of a metabolic activation system (S9 mix). Our results indicate that rotenone increases the frequency of binucleated micronucle- ated (BNMN)cells and causes a delay in the cell cycle but does not increase the frequency of CA and SCE at the concentrations used. The presence of S9 mix reduces the genotoxic activity of rotenone.
Description7 páginas y 6 tablas estadísticas
URIhttp://hdl.handle.net/10261/93728
Appears in Collections:(ICA) Artículos
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