English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/93662
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 5 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Combining rimonabant and fentanyl in a single entity: Preparation and pharmacological results

Autor Fernández-Fernández, Cristina ; Callado, Luis F.; Girón, Rocío; Sánchez, Eva; Erdozain, Amaia M.; López-Moreno, José Antonio; Morales, Paula ; Rodriguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar ; Meana, J. Javier; Martín, M. Isabel ; Jagerovic, Nadine
Palabras clave fentanyl
rimonabant
cannabinoid
opioid
behavioral assays
Fecha de publicación 2014
Citación Drug Design, Development and Therapy 8: 263- 277 (2014)
ResumenBased on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two wellknown drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 and CB2 cannabinoid and μ opioid receptors. In [35S]-GTPγS (guanosine 5'-O-[gamma-thio]triphosphate) binding assays from the post-mortem human frontal cortex, they proved to be CB1 cannabinoid antagonists and μ opioid antagonists. Interestingly, in vivo, the new compounds exhibited a significant dual antagonist action on the endocannabinoid and opioid systems. © 2014 Fernández-Fernández et al.
URI http://hdl.handle.net/10261/93662
DOI10.2147/DDDT.S55045
Identificadoresdoi: 10.2147/DDDT.S55045
issn: 1177-8881
Aparece en las colecciones: (IQM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.