Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/9350
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

The many faces of VIP in neuroimmunology: a cytokine rather a neuropeptide?

AutorPozo Pérez, David; Delgado, M.
Palabras claveImmune response
Autoimmunity
Th cells
Vasoactive intestinal peptide
Fecha de publicaciónsep-2004
EditorFederation of American Societies for Experimental Biology
CitaciónThe FASEB Journal 18: 1325-1334 (2004)
ResumenNeuroimmunomodulation has experienced an explosive growth not only in basic research, but expanding to the point that prospective clinical research could be now a reality. A crucial factor for the functioning of this intimate bidirectional network was the demonstration that the immune and neuroendocrine systems speak a mutual biochemical language. This implies 1) production of neuroendocrine hormones and neuropeptides by immune cells and of cytokines by neuroendocrine cells; 2) evidence for shared receptors on cells of the immune and neuroendocrine systems; 3) effect of neuroendocrine mediators on immune functions; and 4) effect of cytokines on the neuroendocrine system. This reduces traditional differences between neurotransmitters, hormones, and immune mediators and raises the following question: what can we now regard as immune or neuroendocrine? Vasoactive intestinal peptide (VIP) is one example of this paradigm. VIP has traditionally been classified as a neuropeptide/neurotransmitter based in its capacity to mediate and regulate neuronal functions. Recent work has demonstrated that VIP is produced by T cells, especially Th2 cells, and that through specific receptors it exerts immunological functions typically ascribed to Th2 cytokines in nervous and immune systems. Here, we postulate that instead of a neuropeptide, VIP could be fully considered a type 2 cytokine with a key role in neuroimmunology.
Descripción10 pages, 3 figures.-- PMID: 15333575 [PubMed].
Versión del editorhttp://dx.doi.org/10.1096/fj.03-1440hyp
URIhttp://hdl.handle.net/10261/9350
DOI10.1096/fj.03-1440hyp
ISSN0892-6638
Aparece en las colecciones: (IPBLN) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Pozo_Delgado_FASEB_Journal_2004.pdf2,16 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

80
checked on 12-mar-2024

WEB OF SCIENCETM
Citations

73
checked on 27-feb-2024

Page view(s)

367
checked on 27-mar-2024

Download(s)

400
checked on 27-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.