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Título: | The many faces of VIP in neuroimmunology: a cytokine rather a neuropeptide? |
Autor: | Pozo Pérez, David; Delgado, M. | Palabras clave: | Immune response Autoimmunity Th cells Vasoactive intestinal peptide |
Fecha de publicación: | sep-2004 | Editor: | Federation of American Societies for Experimental Biology | Citación: | The FASEB Journal 18: 1325-1334 (2004) | Resumen: | Neuroimmunomodulation has experienced an explosive growth not only in basic research, but expanding to the point that prospective clinical research could be now a reality. A crucial factor for the functioning of this intimate bidirectional network was the demonstration that the immune and neuroendocrine systems speak a mutual biochemical language. This implies 1) production of neuroendocrine hormones and neuropeptides by immune cells and of cytokines by neuroendocrine cells; 2) evidence for shared receptors on cells of the immune and neuroendocrine systems; 3) effect of neuroendocrine mediators on immune functions; and 4) effect of cytokines on the neuroendocrine system. This reduces traditional differences between neurotransmitters, hormones, and immune mediators and raises the following question: what can we now regard as immune or neuroendocrine? Vasoactive intestinal peptide (VIP) is one example of this paradigm. VIP has traditionally been classified as a neuropeptide/neurotransmitter based in its capacity to mediate and regulate neuronal functions. Recent work has demonstrated that VIP is produced by T cells, especially Th2 cells, and that through specific receptors it exerts immunological functions typically ascribed to Th2 cytokines in nervous and immune systems. Here, we postulate that instead of a neuropeptide, VIP could be fully considered a type 2 cytokine with a key role in neuroimmunology. | Descripción: | 10 pages, 3 figures.-- PMID: 15333575 [PubMed]. | Versión del editor: | http://dx.doi.org/10.1096/fj.03-1440hyp | URI: | http://hdl.handle.net/10261/9350 | DOI: | 10.1096/fj.03-1440hyp | ISSN: | 0892-6638 |
Aparece en las colecciones: | (IPBLN) Artículos |
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Pozo_Delgado_FASEB_Journal_2004.pdf | 2,16 MB | Adobe PDF | Visualizar/Abrir |
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