English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/93051
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Improving the effectiveness of artificial microRNA (amir)-mediated resistance against turnip mosaic virus by combining two amirs or by targeting highly conserved viral genomic regions

AuthorsElena, Santiago F. ; Lafforgue, Guillaume ; Martínez, Fernando ; Niu, Qi-Wen; Chua, Nam-Hai; Daròs Arnau, José Antonio
KeywordsINHIBITION
EXPRESSION
REPLICATION
ESCAPE
RNA INTERFERENCE
Issue Date2013
PublisherAmerican Society for Microbiology
CitationJournal of Virology 87:(14) 8254- 8256 (2013)
AbstractA drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for improving the effectiveness of resistance in plants. First, we expressed two amiRs complementary to independent targets in the viral genome, and second, we designed amiRs complementary to highly conserved RNA motifs in the viral genome. © 2013, American Society for Microbiology.
URIhttp://hdl.handle.net/10261/93051
DOI10.1128/JVI.00914-13
Identifiersdoi: 10.1128/JVI.00914-13
issn: 0022-538X
Appears in Collections:(IBMCP) Artículos
Files in This Item:
File Description SizeFormat 
Lafforgue et al J. Virol.pdf457,15 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.