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Título

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity

AutorFernández-Millán, Elisa; Ramos, Sonia ; Álvarez, Carmen; Bravo, Laura ; Goya, Luis ; Martín, M. Ángeles
Palabras claveDietary polyphenols
INS-1E beta cells
Oxidative stress
Type 2 diabetes mellitus
Fecha de publicación31-ene-2014
EditorElsevier
CitaciónFood and Chemical Toxicology 66: 245–253 (2014)
ResumenOxidative stress is accepted as one of the causes of beta cell failure in type 2 diabetes. Therefore, identification of natural antioxidant agents that preserve beta cell mass and function is considered an interesting strategy to prevent or treat diabetes. Recent evidences indicated that colonic metabolites derived from flavonoids could possess beneficial effects on various tissues. The aim of this work was to establish the potential anti-diabetic properties of the microbial-derived flavonoid metabolites 3,4-dihydroxyphenylacetic acid (DHPAA), 2,3-dihydroxybenzoic acid (DHBA) and 3-hydroxyphenylpropionic acid (HPPA). To this end, we tested their ability to influence beta cell function and to protect against tert-butyl hydroperoxide-induced beta cell toxicity. DHPAA and HPPA were able to potentiate glucose-stimulated insulin secretion (GSIS) in a beta cell line INS-1E and in rat pancreatic islets. Moreover, pre-treatment of cells with both compounds protected against beta cell dysfunction and death induced by the pro-oxidant. Finally, experiments with pharmacological inhibitors indicate that these effects were mediated by the activation of protein kinase C and the extracellular regulated kinases pathways. Altogether, these findings strongly suggest that the microbial-derived flavonoid metabolites DHPAA and HPPA may have anti-diabetic potential by promoting survival and function of pancreatic beta cells.
Descripción9 páginas,7 figuras, 1 tabla
Versión del editorhttp://dx.doi.org/10.1016/j.fct.2014.01.044
URIhttp://hdl.handle.net/10261/93011
DOI10.1016/j.fct.2014.01.044
ISSN0278-6915
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