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Título

Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells.

AutorVillorbina, Gemma; Canals, Daniel; Carde, Lydia; Grijalvo, Santiago; Pascual, Rosalia; Rabal, Obdulia; Teixidó, Jordi; Fabriàs, Gemma; Llebaria, Amadeu; Casas Brugulat, Josefina; Delgado Cirilo, Antonio
Palabras claveCombinatorial
Ceramide
Dihydroceramide
Sphingolipid
Analogues
Apoptosis
COPD
Fecha de publicación1-ene-2007
EditorElsevier
CitaciónBioorganic & Medicinal Chemistry 15(1): 50-62 (2007)
ResumenSolid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely due to the threo isomers, as evidenced by cellular studies with a pair of diastereomerically pure N-acyldihydrosphingosines. The apoptotic activity reported in this work provides information for the design of new compounds that may provide the basis for the generation of biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involve.
Descripción13 páginas,4 tablas, 1 esquema.
Versión del editorhttp://dx.doi.org/10.1016/j.bcm.2006.10.024
URIhttp://hdl.handle.net/10261/9299
DOI10.1016/j.bcm.2006.10.024
ISSN1464-3391
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