English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/92932
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

The relationship between cotinine concentrations and inflammatory markers among highly secondhand smoke exposed non-smoking adolescents

AutorMatsunaga, Y.; Vardavas, C. I.; Plada, M.; Wärnberg, Julia; Gómez Martínez, Sonia ; Tzatzarakis, M.; Tsatsakis, A. M.; Díaz, L. E. ; Marcos, Ascensión ; Kafatos, A.
Palabras claveInflammatory marker
Cotinine
HELENA study
Secondhand smoke exposure
Adolescent
Fecha de publicación2014
EditorElsevier
CitaciónCytokine 66: 17- 22 (2014)
ResumenBackground: Secondhand smoke (SHS) exposure is a risk factor of respiratory, cardiovascular and inflammatory diseases, however its association with inflammatory markers among highly SHS exposed adolescents has not yet been explored. Methods: Participants included in this study were a subset of 68 non-smoking adolescents, aged 12.5-17.5 from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, recruited from Crete Greece. Smoking and SHS exposure was assessed via serum cotinine concentrations. Cytokines (Interleukin-1β, 2, 4, 5 and 6, tumor necrosis factor-α, interferon-γ, tumor growth factor-β1), immunoglobulins IgG, IgA, IgM, complement factors C3, C4, high sensitivity C-reactive protein, and endothelial inflammatory markers [soluble E-selectin, soluble L-selectin, soluble intercellular adhesion molecules (sICAM-1) and soluble vascular cell adhesion molecules-1 (sVCAM-1)] were assessed. Inflammatory markers in the lower 25th percentile and upper 75th percentile groups of cotinine levels were compared and multivariate linear regression analysis was performed controlling for age, sex and BMI. Results: Cotinine concentrations were notably elevated (geometric mean 0.82. ng/ml, 95%CI 0.62-1.07) in this study population. A significant decrease in IL-4 (130.09 vs. 25.77. pg/ml, p= 0.014) and IL-6 (19.52 vs. 5.52. pg/ml, p=. 0.008) concentrations between the upper 75th percentile cotinine level group and lower 25th percentile cotinine level group was observed. In a multivariate linear regression analysis, cotinine concentrations had a weak inverse association with IL-4 and IL-6 (p= 0.028 and p=. 0.06) which was not statistically significant when adjusted for multiple comparisons (modified Bonferroni, p>. 0.016). No differences in the other variables was noted. Conclusions: Among highly SHS exposed adolescents, cotinine levels had weak inverse association with IL-4 and IL-6, which did not achieve statistical significance. However, our results potentially indicate an immunosuppressive role of SHS. Further research is warranted to explore this hypothesis. © 2013 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/92932
DOI10.1016/j.cyto.2013.12.007
Identificadoresdoi: 10.1016/j.cyto.2013.12.007
issn: 1043-4666
Aparece en las colecciones: (ICTAN) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.