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Title

Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis

AuthorsDe la Hera, Belén; Varadé, J.; García-Montojo, Marta; Alcina, Antonio; Fedetz, María; Alloza, I.; Astobiza, Ianire; Leyva, Laura; Fernández, Óscar; Izquierdo, Guillermo; Antigüedad, A.; Arroyo, R.; Álvarez-Lafuente, Roberto; Vandenbroeck, Koen; Matesanz, F.; Urcelay, Elena
Issue Date3-Mar-2014
PublisherPublic Library of Science
CitationPLoS ONE
AbstractBackground Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11–1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14–1.53)]. Conclusion Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts.
Publisher version (URL)http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090182#ack
URIhttp://hdl.handle.net/10261/92912
DOI10.1371/journal.pone.0090182
ISSN1932-6203
E-ISSN1932-6203
Appears in Collections:(IPBLN) Artículos
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