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Título

Impedimetric immunosensor for the specific label free detection of ciprofloxacin antibiotic

Autor Ionescu, Rodica E.; Jaffrezic-Renault, Nicole; Bouffier, Laurent; Gondran, Chantal; Cosnier, Serge; Pinacho, Daniel G.; Marco, María Pilar; Sánchez Baeza, Francisco J.; Healy, Thomas; Martelet, Claude
Palabras clave Ciprofloxacin
Immunosensor
Polypyrrole
Impedance spectroscopy
Fecha de publicación 2-ago-2007
EditorElsevier
Citación Biosensors & Bioelectronics 23(4): 549-555 (2007)
ResumenImpedance spectroscopy approaches combined with the immunosensor technology have been used for the determination of trace amounts of ciprofloxacin antibiotic belonging to the fluoroquinolone family. The sensor electrode was based on the immobilization of anti-ciprofloxacin antibodies by chemical binding onto a poly(pyrrole-NHS) film electrogenerated on a solid gold substrate. The electrode surface was modified by electropolymerization of pyrrole-NHS, antibody grafting and ciprofloxacin immunoreaction. The sensitive steps of surface modification, cyclic voltammetry (CV) and atomic force microscopy (AFM) imaging have been used for electrode surface characterization.
The immunoreaction of ciprofloxacin on the grafted anti-ciprofloxacin antibody directly triggers a signal via impedance spectroscopy measurements which allows the detection of extremely low concentration of 10 pg/ml ciprofloxacin.
Descripción 7 pages, 6 figures.-- PMID: 17826084 [PubMed].-- Printed version published on Nov 30, 2007.
Versión del editorhttp://dx.doi.org/10.1016/j.bios.2007.07.014
URI http://hdl.handle.net/10261/9270
DOI10.1016/j.bios.2007.07.014
ISSN0956-5663
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