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Quinolyl nitrones

Other TitlesQuinolilnitronas
AuthorsChioua, Mourad ; Samadi, Abdelouahid ; Soriano, Elena ; Marco-Contelles, José ; Oset Gasque, María Jesús; Alcázar González, Alberto
Issue Date7-Feb-2013
CitationWO2013017715 A2
Abstract[EN] The invention relates to quinolyl nitrones with the formula (I), with high permeability to the hematoencephalic barrier and antioxidant and neuroprotective capacity, as potential pharmaceuticals for the treatment of ictus, cerebral ischemia and other neurodegenerative diseases such as Alzheimer's, Parkinson's and amyotrophic lateral sclerosis, where X represents halogen, amino groups (substituted or not), alkoxy as methoxy, ethoxy, benzyloxy or thiophenyl.; R1, R2 and R3 independently represent an alkyl radical C1-C6, (substituted or not), a phenyl group or aromatic ring with one or more heteroatoms, and substituted by groups of hdyroxyl, methoxy, trifluoromethyl, nitro, cyano, carbaldehyde, carboxylic, carboxylic ester, halogen or alkyl radical C1-C6 (substituted or not) and that are found in positions C2' 3' or 4' of the benzene ring or are heterocyclic with five or six links, such as furane, thiophene, pyrrole, pyridine, pyracin, pyradazine, pyramidine or indole.
[ES] Quinolilnitronas de fórmula (I), con alta permeabilidad a la barrera hematoencefálica, capacidad antioxidante, y neuprotectora, como potenciales fármacos para el tratamiento de del ictus, isquemía cerebral, y de otras enfermedades neurodegenerativas como Alzheimer, Parkinson, y esclerosis laterail amiotróofica, y donde, X representa halógeno, grupos amino substituidos o no, alcoxi como metoxi, etoxi, benciloxi, o tiofenilo. R1, R2 y R3 representan independientemente un radical alquilo C1-C6, sustituidos o no, grupo fenilo, o anillo aromático con uno o varios heteroátomos, y sustituidos por grupos hydroxilo, metoxi, trifluorometilo, nitro, ciano, carbaldehido, carboxilico, ester carboxilico, halógeno, o radigal alquilo C1-C6, sustituido o no, y que se encuentran en las posiciones C2' 3' o 4' del anillo bencénico, o heterocíclico de cinco o seis eslabones, tal coomo furano, tiofeno, pirrol, piridina, piracina, piridacina, piriimidina, indol.
Appears in Collections:(IQOG) Patentes
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