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Title

Smallest Peptoids with Antiproliferative Activity on Human Neoplastic Cells

AuthorsMas Moruno, Carlos; Cruz, Luis J.; Mora, Puig; Francesch, Andrés; Messeguer Peypoch, Ángel ; Pérez-Payá, Enrique ; Albericio, Fernando
KeywordsPeptoids
Antiproliferative activity
Solid phase synthesis
Diketopiperazines
Issue Date4-Apr-2007
PublisherAmerican Chemical Society
CitationJournal Medicinal Chemistry Research; vol 50, 2443-2449
AbstractLibraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis.
Description7 paginas; 5 tablas; 2 esquemas.
Publisher version (URL)http://dx.doi.org/10.1021/jm061166z
URIhttp://hdl.handle.net/10261/9250
DOI10.1021/jm061166z
ISSN1554-8120
Appears in Collections:(IQAC) Artículos
(IBV) Artículos
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