English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/9250
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Smallest Peptoids with Antiproliferative Activity on Human Neoplastic Cells

AuthorsMas Moruno, Carlos; Cruz, Luis J.; Mora, Puig; Francesch, Andrés; Messeguer Peypoch, Ángel ; Pérez-Payá, Enrique ; Albericio, Fernando
Antiproliferative activity
Solid phase synthesis
Issue Date4-Apr-2007
PublisherAmerican Chemical Society
CitationJournal Medicinal Chemistry Research; vol 50, 2443-2449
AbstractLibraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis.
Description7 paginas; 5 tablas; 2 esquemas.
Publisher version (URL)http://dx.doi.org/10.1021/jm061166z
Appears in Collections:(IQAC) Artículos
(IBV) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.