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Title

Heterocyclic GSK-3 allosteric modulators

Other TitlesModuladores alostéricos de GSK-3 de naturaleza heterocíclica
AuthorsMartínez, Ana ; Gil, Carmen ; Palomo, Valle ; Pérez Martín, María Concepción; Pérez Fernández, Daniel Ignacio ; Reyes Rodríguez, Julio Alberto
Issue Date4-Apr-2013
CitationWO2013045736 A1
Abstract[EN] The invention relates to heterocyclic derivatives of substituted quinolines as allosteric inhibitors of the glycogen synthase kinase 3 (GSK-3) enzyme. Thus, said compounds can be used in the production of a drug for the treatment and/or prevention of diseases in which GSK-3 is involved, such as: neurodegenerative diseases, inflammatory diseases, cancer and diabetes, as well as to promote a plurality of regenerative processes.
[ES] La presente invención se refiere a derivados heterocíclicos de quiloninas sustiuidas como inhibidores alostéricos del enzima glucógeno sintasa quinasa 3 (GSK-3). Estos compuestos, por tanto, son útiles para la fabricación de un medicamento para el tratamiento y/o prevención de enfermedades en las que GSK-3 esté implicada, tales como, enfermedades neurodegenerativas, enfermedades inflamatorias, cáncer, diabetes, así como para promover diversos procesos regenerativos.
URIhttp://hdl.handle.net/10261/92301
Appears in Collections:(IQM) Patentes
(CIB) Patentes
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