English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/92296
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep

AutorCastaño, P.; Fuertes, M. ; Fernández Fernández, M. ; Ferreras, Mª del Carmen ; González Lanza, Camino ; Pérez Pérez, Valentín ; Benavides, Julio
Palabras claveAcquired-immunodeficiency-syndrome
Ovine toxoplasmosis
Pregnant sheep
Fecha de publicación29-ene-2014
EditorBioMed Central
CitaciónVeterinary Research 45: 9 (2014)
ResumenAfter oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their development.
Versión del editorhttp://dx.doi.org/10.1186/1297-9716-45-9
Aparece en las colecciones: (IGM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
1297-9716-45-9.xml82,88 kBXMLVisualizar/Abrir
1297-9716-45-9.pdf1,72 MBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.