English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/92126
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Protection against age-related neuronal frailty by sirtuin 1 enhancement

AuthorsCorpas, Rubén ; Cristòfol, Rosa ; Porquet, David; Camins, Antoni; Pallàs, Mercè; Sanfeliu, Coral
Issue DateJul-2012
Citation8th FENS (2012)
AbstractIn aging and in the diseases associated with the elderly occurs a progressive cognitive loss caused by deteriorating brain function. Sirtuin 1, a member of the sirtuin family of protein deacetylases, is involved in lifespan extension and is considered a neuroprotective protein. The senescence-accelerated prone 8 (SAMP8) mouse, an accelerated aging model, presents an early age-related pattern and shows overproduction of Aß and p-tau. In this study, we performed functional assays of mitochondrial activity and oxidative stress in cultures of neurons from SAMP8 and senescence-accelerated-resistant (SAMR1) mice models to examine the status of neurons with emphasis in the mitochondrial function. The SAMP8 mitochondria presented lower membrane potential and higher vulnerability to mitochondrial damaging agents than SAMR1 mitochondria. This increased vulnerability indicated the presence of a senescence-associated frailty stage in SAMP8 neurons. We assayed the neuroprotective effects of resveratrol, a known Sirtuin 1 enhancer agent, and that of melatonin, also effective in anti-aging mechanisms. Here we show that both, resveratrol and melatonin, protected against the senescence-associated mitochondrial frailty stage in SAMP8 mouse neurons. Mechanisms involved included the enhancement of sirtuin1 expression and antioxidant mechanisms. The beneficial neuronal effects of Sirtuin 1 promoting agents makes this molecule a promising anti-aging target. New studies of Sirtuin 1 overexpression by using lentiviral vectors are ongoing.
DescriptionTrabajo presentado al 8th Forum of Neuroscience (FENS) celebrado en Barcelona del 14 al 18 de julio de 2012.
Appears in Collections:(IIBB) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.