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dc.contributor.author | Cénit, M. Carmen | - |
dc.contributor.author | Márquez, Ana | - |
dc.contributor.author | Cordero-Coma, Miguel | - |
dc.contributor.author | Gorroño-Echebarría, M.B. | - |
dc.contributor.author | Fonollosa, Alejandro | - |
dc.contributor.author | Adán, Alfredo | - |
dc.contributor.author | Martínez-Berriotxoa, Agustín | - |
dc.contributor.author | Díaz Valle, David | - |
dc.contributor.author | Pato, Esperanza | - |
dc.contributor.author | Blanco, Ricardo | - |
dc.contributor.author | Cañal, Joaquín | - |
dc.contributor.author | Díaz-Llopis, Manuel | - |
dc.contributor.author | García Serrano, José L. | - |
dc.contributor.author | Ramón, Enrique de | - |
dc.contributor.author | Rio, María J. del | - |
dc.contributor.author | Martín-Villa, José M. | - |
dc.contributor.author | Molins, Blanca | - |
dc.contributor.author | Ortego-Centeno, N. | - |
dc.contributor.author | Martín, J. | - |
dc.date.accessioned | 2014-02-19T12:46:32Z | - |
dc.date.available | 2014-02-19T12:46:32Z | - |
dc.date.issued | 2013-11-29 | - |
dc.identifier.uri | http://hdl.handle.net/10261/92051 | - |
dc.description.abstract | OBJECTIVE: STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes. METHODS: Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. RESULTS: No statistically significant differences were found when allele and genotype distributions were compared between non-anterior uveitis patients and controls for any STAT4 (rs3821236: P=0.39, OR=1.12, CI 95%=0.87-1.43; rs7574865: P=0.59 OR=1.07, CI 95%=0.84-1.37; rs7574070: P=0.26, OR=0.89, CI 95%=0.72-1.10; rs897200: P=0.22, OR=0.88, CI 95%=0.71-1.08;) or IL23R polymorphisms (rs7517847: P=0.49, OR=1.08, CI 95%=0.87-1.33; rs11209026: P=0.26, OR=0.78, CI 95%=0.51-1.21; rs1495965: P=0.51, OR=0.93, CI 95%=0.76-1.15). CONCLUSION: Our results do not support a relevant role, similar to that described for other autoimmune diseases, of IL23R and STAT4 polymorphisms in the non-anterior uveitis genetic predisposition. Further studies are needed to discard a possible weak effect of the studied variant. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | es_ES |
dc.title | No Evidence of Association between Common Autoimmunity STAT4 and IL23R Risk Polymorphisms and Non-Anterior Uveitis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0072892 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0072892 | es_ES |
dc.identifier.e-issn | 1932-6203 | - |
dc.identifier.pmid | 24312163 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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