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Title

Noninvasive molecular imaging of neuroinflammation

AuthorsJacobs, Andreas H.; Tavitian, Bertrand; Planas, Anna M.
KeywordsAlzheimer's disease
Cerebral ischemia
Inflammation
Multiple sclerosis
Microglia
Molecular imaging
Issue Date2012
PublisherNature Publishing Group
CitationJournal of Cerebral Blood Flow and Metabolism 32(7): 1393-1415 (2012)
AbstractInflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases of the CNS, such as stroke, multiple sclerosis (MS), and neurodegeneration, elicit a neuroinflammatory response with the goal to limit the extent of the disease and to support repair and regeneration. However, various disease mechanisms lead to neuroinflammation (NI) contributing to the disease process itself. Molecular imaging is the method of choice to try to decipher key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the orchestrated inflammatory response in vivo in animal models and patients. Here, we review the basic principles of NI with emphasis on microglia and common neurologic disease mechanisms, the molecular targets which are being used and explored for imaging, and molecular imaging of NI in frequent neurologic diseases, such as stroke, MS, neurodegeneration, epilepsy, encephalitis, and gliomas.
DescriptionThis work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License.-- The INMiND consortium: et al.
Publisher version (URL)http://dx.doi.org/10.1038/jcbfm.2012.53
URIhttp://hdl.handle.net/10261/90720
DOI10.1038/jcbfm.2012.53
ISSN0271-678X
E-ISSN1559-7016
Appears in Collections:(IIBB) Artículos
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