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dc.contributor.authorGiménez, Estela-
dc.contributor.authorLavado, Alfonso J.-
dc.contributor.authorGiraldo, Patricia-
dc.contributor.authorMontoliu, Lluís-
dc.date.accessioned2008-12-04T09:10:39Z-
dc.date.available2008-12-04T09:10:39Z-
dc.date.issued2003-10-27-
dc.identifier.citationEuropean Journal of Neuroscience 18(9): 2673-2676 (2003)en_US
dc.identifier.issn0953-816X-
dc.identifier.urihttp://hdl.handle.net/10261/8990-
dc.description4 pages, 3 figures.-- PMID: 14622170 [PubMed].en_US
dc.description.abstractTyrosinase is the rate-limiting enzyme for melanin synthesis. Its gene is expressed in two cell types: melanocytes, derived from migrating neural crest cells, and, in the CNS, retinal pigment epithelium cells, derived from the optic cup. Its absence from the eye results in profound pathway selection errors of optic fibres at the chiasm and, hence, it has been implicated as a developmental regulator of CNS pathway selection. Recently, it has been proposed that tyrosinase can also be expressed in the developing and adult brain, although the methods used were indirect. Its presence in the brain could be very significant in terms of a potentially wider role in pathway finding. Here, we have evaluated the presence of tyrosinase expression in mouse developing, perinatal and adult brain by in situ hybridization in whole-mount embryos and histological sections and by real-time reverse transcription–polymerase chain reaction. We find no evidence for tyrosinase gene expression in the CNS outside the retinal pigment epithelium cells.en_US
dc.description.sponsorshipThis work was supported by funds from the Spanish Ministry of Science and Technology Bio97-0628, Bio2000-1653, FEDER 2FD1997-2059 and Laboratorios Dr. Esteve S.A. to L.M.en_US
dc.format.extent136176 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherFederation of European Neuroscience Societiesen_US
dc.publisherBlackwell Publishing-
dc.rightsclosedAccessen_US
dc.subjectEctopicen_US
dc.subjectExpression patternen_US
dc.subjectlacZen_US
dc.subjectMelaninen_US
dc.subjectRetinaen_US
dc.subjectTelencephalonen_US
dc.titleTyrosinase gene expression is not detected in mouse brain outside the retinal pigment epithelium cellsen_US
dc.typeArtículoen_US
dc.identifier.doi10.1046/j.1460-9568.2003.02992.x-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1046/j.1460-9568.2003.02992.xen_US
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