English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/8990
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 21 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar bibText (RIS)Exportar csv (RIS)
Título

Tyrosinase gene expression is not detected in mouse brain outside the retinal pigment epithelium cells

Autor Giménez, Estela; Lavado, Alfonso J.; Giraldo, Patricia; Montoliu, Lluís
Palabras clave Ectopic
Expression pattern
lacZ
Melanin
Retina
Telencephalon
Fecha de publicación 27-oct-2003
EditorFederation of European Neuroscience Societies
Blackwell Publishing
Citación European Journal of Neuroscience 18(9): 2673-2676 (2003)
ResumenTyrosinase is the rate-limiting enzyme for melanin synthesis. Its gene is expressed in two cell types: melanocytes, derived from migrating neural crest cells, and, in the CNS, retinal pigment epithelium cells, derived from the optic cup. Its absence from the eye results in profound pathway selection errors of optic fibres at the chiasm and, hence, it has been implicated as a developmental regulator of CNS pathway selection. Recently, it has been proposed that tyrosinase can also be expressed in the developing and adult brain, although the methods used were indirect. Its presence in the brain could be very significant in terms of a potentially wider role in pathway finding. Here, we have evaluated the presence of tyrosinase expression in mouse developing, perinatal and adult brain by in situ hybridization in whole-mount embryos and histological sections and by real-time reverse transcription–polymerase chain reaction. We find no evidence for tyrosinase gene expression in the CNS outside the retinal pigment epithelium cells.
Descripción 4 pages, 3 figures.-- PMID: 14622170 [PubMed].
Versión del editorhttp://dx.doi.org/10.1046/j.1460-9568.2003.02992.x
URI http://hdl.handle.net/10261/8990
DOI10.1046/j.1460-9568.2003.02992.x
ISSN0953-816X
Aparece en las colecciones: (CNB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.