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Título

Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice

Autor Langa, Francina; Codony, Xavier; Tovar, Victoria; Lavado, Alfonso J.; Giménez, Estela; Cozar, Patricia; Cantero, Marta; Dordal, Albert; Hernández, Enric; Pérez, Raquel; Monroy, Xavier; Zamanillo, Daniel; Guitart, Xavier; Montoliu, Lluís
Palabras clave Analgesia
Gene targeting
Schizophrenia
SKF-10 047
Fecha de publicación 22-oct-2003
EditorFederation of European Neuroscience Societies
Blackwell Publishing
Citación European Journal of Neuroscience 18(8): 2188-2196 (2003)
ResumenSigma (σ) sites are a type of nonopiate receptor whose role has been associated with several behaviours, including anxiety, depression, analgesia, learning processes and psychosis. Although there are several known σ receptor types, only the type I receptor (σ1) has been cloned. To uncover the in vivo relevance of σ-receptors, we have generated knockout mice for σ1. Despite the broad expression pattern found for the σ1-gene, homozygous mutant mice are viable, fertile and do not display any overt phenotype, compared with their wild-type litter-mates, in mixed genetic backgrounds. However, a significant decrease in the hypermotility response has been measured in knockout mice upon challenge with (+)SKF-10 047, in agreement with the involvement of σ1-receptors in the induction of psychostimulant actions. The activity of σ2-receptors seems to be unaffected in σ1-mutant mice. These knockout mice could contribute to better understand the in vivo role of σ-receptors.
Descripción 9 pages, 6 figures.-- PMID: 14622179 [PubMed].
Versión del editorhttp://dx.doi.org/10.1046/j.1460-9568.2003.02950.x
URI http://hdl.handle.net/10261/8982
DOI10.1046/j.1460-9568.2003.02950.x
ISSN0953-816X
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