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dc.contributor.authorGiménez-Llort, Lydia-
dc.contributor.authorCanela. Laia-
dc.contributor.authorCamón, LLuïsa-
dc.contributor.authorFerré, Sergi-
dc.contributor.authorCiruela, Francisco-
dc.contributor.authorMartínez, Emili-
dc.contributor.authorFranco, Rafael-
dc.contributor.authorFuxe, Kjell-
dc.contributor.authorBader, Michael-
dc.date.accessioned2014-01-15T13:56:00Z-
dc.date.available2014-01-15T13:56:00Z-
dc.date.issued2007-
dc.identifierdoi: 10.1016/j.nlm.2006.05.004-
dc.identifierissn: 1074-7427-
dc.identifiere-issn: 1095-9564-
dc.identifier.citationNeurobiology of Learning and Memory 87(1): 42-56 (2007)-
dc.identifier.urihttp://hdl.handle.net/10261/89515-
dc.description.abstractAdenosine receptors in the central nervous system have been implicated in the modulation of different behavioural patterns and cognitive functions although the specific role of A2A receptor (A2AR) subtype in learning and memory is still unclear. In the present work we establish a novel transgenic rat strain, TGR(NSEhA2A), overexpressing adenosine A2ARs mainly in the cerebral cortex, the hippocampal formation, and the cerebellum. Thereafter, we explore the relevance of this A2ARs overexpression for learning and memory function. Animals were behaviourally assessed in several learning and memory tasks (6-arms radial tunnel maze, T-maze, object recognition, and several Morris water maze paradigms) and other tests for spontaneous motor activity (open field, hexagonal tunnel maze) and anxiety (plus maze) as modification of these behaviours may interfere with the assessment of cognitive function. Neither motor performance and emotional/anxious-like behaviours were altered by overexpression of A2ARs. TGR(NSEhA2A) showed normal hippocampal-dependent learning of spatial reference memory. However, they presented working memory deficits as detected by performance of constant errors in the blind arms of the 6 arm radial tunnel maze, reduced recognition of a novel object and a lack of learning improvement over four trials on the same day which was not observed over consecutive days in a repeated acquisition paradigm in the Morris water maze. Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A2ARs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients. © 2006 Elsevier Inc. All rights reserved.-
dc.description.sponsorshipThis work was supported by an EC grant (QLG3-CT-2001-01056), the Swedish Research Council, Programa Ramon y Cajal and Fundació Marató-TV3 núm. 014110, grants from Ministerio de Ciencia y Tecnología SAF2002-03293 to R.F., Grant 02/056-00 from Fundacio la Caixa for R.F., Grants 01/012710 from Fundació Marató TV3 for R.F., and grants of the Fonds National de la Recherche Scientifique (SNS), Queen Elisabeth Medical Foundation (SNS), Van Buuren Foundation (SNS), and Action de Recherche Concertée (SNS).-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.subjectHeterodimerization-
dc.subjectMemory-
dc.subjectTransgenic rat-
dc.subjectDopamine receptors-
dc.subjectAdenosine receptors-
dc.subjectPrefrontal cortex-
dc.titleWorking memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.nlm.2006.05.004-
dc.date.updated2014-01-15T13:56:00Z-
dc.description.versionPeer Reviewed-
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