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dc.contributor.author | Morales, Albert | - |
dc.contributor.author | Goñi, Félix M. | - |
dc.contributor.author | Fernández-Checa, José C. | - |
dc.date.accessioned | 2014-01-15T12:09:41Z | - |
dc.date.available | 2014-01-15T12:09:41Z | - |
dc.date.issued | 2007 | - |
dc.identifier | doi: 10.1007/s10495-007-0721-0 | - |
dc.identifier | issn: 1360-8185 | - |
dc.identifier | e-issn: 1573-675X | - |
dc.identifier.citation | Apoptosis 12(5): 923-939 (2007) | - |
dc.identifier.uri | http://hdl.handle.net/10261/89480 | - |
dc.description.abstract | Sphingolipids (SLs) have been considered for many years as predominant building blocks of biological membranes with key structural functions and little relevance in cellular signaling. However, this view has changed dramatically in recent years with the recognition that certain SLs such as ceramide, sphingosine 1-phosphate and gangliosides, participate actively in signal transduction pathways, regulating many different cell functions such as proliferation, differentiation, adhesion and cell death. In particular, ceramide has attracted considerable attention in cell biology and biophysics due to its key role in the modulation of membrane physical properties, signaling and cell death regulation. This latter function is largely exerted by the ability of ceramide to activate the major pathways governing cell death such as the endoplasmic reticulum and mitochondria. Overall, the evidence so far indicates a key function of SLs in disease pathogenesis and hence their regulation may be of potential therapeutic relevance in different pathologies including liver diseases, neurodegeneration and cancer biology and therapy. © 2007 Springer Science + Business Media, LLC. | - |
dc.description.sponsorship | The work presented was supported in part by the Research Center for Liver and Pancreatic Diseases, P50 AA 11999; and grant 1R21 AA014135, funded by the US National Institute on Alcohol Abuse and Alcoholism; Plan Nacional de I+D grants SAF (2003-04974; 2006-06780); and Red Temática de Investigación Cooperativa G03/015, Red de Centros C03/02, PI 05/1285 and FIS (06/0395) supported by Instituto de Salud Carlos III, Spain, and the European Lipidomics Initiative (Elife). A.M. is a Ramon y Cajal investigator. | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.rights | closedAccess | - |
dc.subject | Mitochondria | - |
dc.subject | Ceramide | - |
dc.subject | Transbilayer trafficking | - |
dc.subject | Endoplasmic reticulum | - |
dc.subject | Gangliosides | - |
dc.subject | Membranes | - |
dc.title | Sphingolipids and cell death | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s10495-007-0721-0 | - |
dc.date.updated | 2014-01-15T12:09:42Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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