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Title

In vivo biological activity of rocket extracts (Eruca vesicaria subsp. sativa (Miller) Thell) and sulforaphane

AuthorsVillatoro Pulido, Myriam; Font, Rafael ; Saha, Shikha; Obregón, Sara ; Anter, Jauoad; Muñoz Serrano, Andrés; Haro Bailón, Antonio de ; Alonso Moraga, Ángeles; Río Celestino, Mercedes del
KeywordsEruca vesicaria subsp. sativa
Rocket
Glucosinolates
Isothiocyanates
Antigenotoxicity
Life span
Issue DateMay-2012
PublisherElsevier
CitationFood and Chemical Toxicology 50(5): 1384-1392 (2012)
AbstractEruca is thought to be an excellent source of antioxidants like phenolic compounds, carotenoids, glucosinolates and their degradation products, such as isothiocyanates. Sulforaphane is one of the most potent indirect antioxidants of Eruca isolated until the date. In this work we investigate: (i) the safety and DNA protective activity of Eruca extracts and sulforaphane (under and without oxidative stress) in Drosophila melanogaster; and (ii) the influence on D. melanogaster life span treated with Eruca extracts and sulforaphane. Our results showed that among the four concentrations of Eruca extracts tested (from 0.625 to 5. mg/ml), intermediate concentrations of the Es2 accession (1.25 and 2.5. mg/ml) exhibited no genotoxic activity, as well as antigenotoxic activity (inhibition rate of 0.2-0.6) and the lowest concentration of Es2 and Es4 accessions (0.625. mg/ml) also enhanced the health span portion of the live span curves. Sulforaphane presented a high antigenotoxic activity in the SMART test of D. melanogaster and intermediate concentrations of this compound (3.75. μM) enhanced average healthspan. The results of this study indicate the presence of potent antigenotoxic factors in rocket, which are being explored further for their mechanism of action. © 2012 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/89347
DOI10.1016/j.fct.2012.02.017
Identifiersdoi: 10.1016/j.fct.2012.02.017
issn: 0278-6915
Appears in Collections:(IAS) Artículos
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