English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/89311
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis

AuthorsFranco-Pons, Neus ; Casas, Josefina ; Fabriàs, Gemma ; Gea-Sorlí, Sabrina ; Madaria, Enrique de; Gelpí, Emili ; Closa, Daniel
KeywordsFatty acid chlorohydrins
Inflammation
Acute pancreatitis
Issue Date2013
PublisherLippincott Williams & Wilkins
CitationAnnals of Surgery 257(5): 943-951 (2013)
Abstract[Objective]: To evaluate the generation of halogenated fatty acids in the areas of fat necrosis during acute pancreatitis and to evaluate the effects of these molecules on the ensuing inflammatory process. [Background]: Lipid mediators derived from adipose tissue have been implicated in the progression of acute pancreatitis, although their precise role remains unknown. [Methods]: Acute pancreatitis was induced in rats by intraductal infusion of 3.5% sodium taurocholate. Fatty acid chlorohydrins (FA-Cl) were measured in adipose tissue, ascitic fluid, and plasma by mass spectrometry. Chlorohydrins were also instilled in the rats' peritoneal cavity, and their effects on peritoneal macrophages activation and in systemic inflammation were evaluated. Finally, they have also been measured in plasma from human patients with acute pancreatitis. [Results]: Induced acute pancreatitis results in a substantial release not only of free fatty acids but also of the chlorohydrins of both oleic and linoleic acids from adipose tissue. In plasma, only the chlorohydrin of oleic acid was detected. Administration of 250-μM lipid chlorohydrins, which is the concentration found in ascitic fluid, induces the expression of TNFα and interleukin-1β in peritoneal macrophages and increases the systemic inflammatory response in pancreatitis. Finally, increased concentrations of oleic acid chlorohydrin have been found in plasma of human patients with pancreatitis. [Conclusions]: During acute pancreatitis, adipose tissue release FA-Cl, which exacerbate the systemic inflammatory response. Copyright © 2013 by Lippincott Williams & Wilkins.
Publisher version (URL)http://dx.doi.org/10.1097/SLA.0b013e318269d536
URIhttp://hdl.handle.net/10261/89311
DOI10.1097/SLA.0b013e318269d536
Identifiersdoi: 10.1097/SLA.0b013e318269d536
issn: 0003-4932
e-issn: 1528-1140
Appears in Collections:(IQAC) Artículos
(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.