English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/89301
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

PAP/HIP protein is an obesogenic factor

AuthorsSecq, Véronique; Mallmann, Cecilia; Gironella, Meritxell; López, Belén; Closa, Daniel ; García, Stéphane; Christa, Laurence; Montalto, Giuseppe; Dusetti, Nelson; Iovanna, Juan Lucio
Issue Date25-Oct-2013
PublisherWiley-Blackwell
CitationJournal of Cellular Physiology 229(2): 225-231 (2014)
AbstractIn this article we report the obesogenic role of the acute phase protein PAP/HIP. We found that the transgenic TgPAP/HIP mice develop spontaneous obesity under standard nutritional conditions, with high levels of glucose, leptin, and LDL and low levels of triglycerides and HDL in blood. Accordingly, PAP/HIP-deficient mice are skinny under standard nutritional conditions. We also found that expression of PAP/HIP is induced in intestinal epithelial cells in response to gavage with olive oil and this induction is AG490 sensitive. We demonstrated that incubation of 3T3-L1 preadipocytes with a low concentration as 1ng/ml of recombinant PAP/HIP results in accelerated BrdU incorporation in vitro. PAP/HIP-dependent adipocytes growth is sensitive to the MEK inhibitor U0126. Finally, patients with severe obesity present higher blood levels of PAP/HIP than non-obese control individuals. Altogether our data suggest that PAP/HIP could be a mediator of fat tissue development, released by the intestine and induced by the presence of food into the gut. © 2013 Wiley Periodicals, Inc.
Publisher version (URL)http://dx.doi.org/10.1002/jcp.24438
URIhttp://hdl.handle.net/10261/89301
DOI10.1002/jcp.24438
Identifiersdoi: 10.1002/jcp.24438
issn: 0021-9541
e-issn: 1097-4652
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.