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Relation between the lipid composition of Brucella membrane and the resistance to cationic peptides

AuthorsPalacios Chaves, Leyre ; Conde Álvarez, Raquel; Zúñiga Ripa, Amaia; Grilló, María Jesús ; Iriarte, Maite; Moriyón, Ignacio; Gutsmann, Thomas
Issue DateSep-2012
CitationAnnual Meeting of the German Biophysical Society (2012)
AbstractThe members of the genus Brucella are α-2 Proteobacteria that cause brucellosis, an important zoonosis. These bacteria trigger only low proinflammatory responses during early infection that allows them to reach sheltered intracellular niches before effective immunity activation. The outer membranes (OM) of brucellae are of critical importance in this strategy. The OM of B. abortus is unusually resistant to antimicrobial peptides (AMPs). Brucella lipopolysaccharide (LPS) is implicated in this property and there is evidence that other lipids (such as phosphatidylcholine) also contribute. Furthermore, these bacteria have acyl chains of average number of carbon units which leads an increase in hydrophobicity, proposed as a biophysical factor underlining AMPs resistance.
DescriptionPóster presentado en el Annual Meeting of the German Biophysical Society, celebrado en Göttingen (Alemania) del 23 al 26 de septiembre de 2012.
Appears in Collections:(IDAB) Comunicaciones congresos
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