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Título

Non-anticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Autor Wildhagen, Karin C.A.A.; García de Frutos, Pablo ; Aresté, Cristina ; Nicolaes, Gerry A. F.
Fecha de publicación 13-feb-2014
EditorAmerican Society of Hematology
Citación Blood 123(7): 1098-1101 (2014)
ResumenExtracellular histones are considered to be major mediators of death in sepsis. Although sepsis is a condition which may benefit from low dose heparin administration, medical doctors need to take into consideration the potential bleeding risk in sepsis patients who are already at increased risk of bleeding due to a consumption coagulopathy. Here we show that mechanisms that are independent of the anticoagulant properties of heparin may contribute to the observed beneficial effects of heparin in the treatment of sepsis patients. We show that non-anticoagulant heparin, purified from clinical grade heparin, binds histones and prevents histone-mediated cytotoxicity in vitro and reduces mortality from sterile inflammation and sepsis in mouse models without increasing the risk of bleeding. Our results demonstrate that administration of non-anticoagulant heparin is a novel and promising approach that may be further developed to treat patients suffering from sepsis.
Descripción Karin C.A.A. Wildhagen et al.
Versión del editorhttp://dx.doi.org/10.1182/blood-2013-07-514984
URI http://hdl.handle.net/10261/89274
DOI10.1182/blood-2013-07-514984
ISSN0006-4971
E-ISSN1528-0020
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