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Resveratrol: New avenues for a natural compound in neuroprotection

AuthorsPallàs, Mercè; Porquet, David; Vicente, Alberto; Sanfeliu, Coral
Sirtuin 1
Issue Date2013
PublisherBentham Science Publishers
CitationCurrent Pharmaceutical Design 19(38): 6726-6731 (2013)
AbstractThis review summarizes the effects of resveratrol in neurodegenerative diseases and speculates on the direction the field will take in the immediate future. In particular, we emphasize studies on the effects of resveratrol on new pathways related to neurodegenerative diseases such as inflammatory processes, mitochondrial biogenesis and its control through gamma coactivator 1- (PGC1 ), and the role of the tandem sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) in neurodegeneration and in neurohormesis. While not all reported results are free from controversy, the demographic shift toward an older population makes compounds with this broad spectrum of potential clinical applications particularly interesting.
DescriptionEl pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.2174/1381612811319380005
Appears in Collections:(IIBB) Artículos
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