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http://hdl.handle.net/10261/89146
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Palacios, José M. | - |
dc.contributor.author | Pazos, Ángel | - |
dc.contributor.author | Hoyer, Danniel | - |
dc.date.accessioned | 2014-01-08T14:13:30Z | - |
dc.date.available | 2014-01-08T14:13:30Z | - |
dc.date.issued | 2011 | - |
dc.identifier | isbn: 978-1-60761-940-6 | - |
dc.identifier.citation | 5-HT2C Receptors in the Pathophysiology of CNS Disease (Cap.1): 1-16 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/89146 | - |
dc.description.abstract | This chapter is a personal account of how the 5-HT2C receptor was discovered and characterized more than 25 years ago. 5-HT2C receptors, initially called 5-HT1C, were found while studying the distribution in the brain of binding sites for the compound mesulergine, a ligand with serotonergic and dopaminergic properties. The strong labeling to choroid plexus revealed a site with pharmacological properties different from the known 5-HT receptors at that time. In the following 10 years, 5-HT1C (later 5-HT2C) was extensively characterized pharmacologically, anatomically, and functionally, leading finally to the cloning of its gene. Since then, intense research has been dedicated to the search a therapeutic use for modulators of these receptors. | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.ispartofseries | The Receptors 22 | - |
dc.rights | closedAccess | - |
dc.title | The making of the 5-HT2C receptor | - |
dc.type | capítulo de libro | - |
dc.date.updated | 2014-01-08T14:13:30Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_3248 | es_ES |
item.openairetype | capítulo de libro | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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