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Título

The making of the 5-HT2C receptor

Autor Palacios, José M.; Pazos, Ángel ; Hoyer, Danniel
Fecha de publicación 2011
EditorSpringer
Citación 5-HT2C Receptors in the Pathophysiology of CNS Disease (Cap.1): 1-16 (2011)
Serie The Receptors 22
ResumenThis chapter is a personal account of how the 5-HT2C receptor was discovered and characterized more than 25 years ago. 5-HT2C receptors, initially called 5-HT1C, were found while studying the distribution in the brain of binding sites for the compound mesulergine, a ligand with serotonergic and dopaminergic properties. The strong labeling to choroid plexus revealed a site with pharmacological properties different from the known 5-HT receptors at that time. In the following 10 years, 5-HT1C (later 5-HT2C) was extensively characterized pharmacologically, anatomically, and functionally, leading finally to the cloning of its gene. Since then, intense research has been dedicated to the search a therapeutic use for modulators of these receptors.
URI http://hdl.handle.net/10261/89146
Identificadoresisbn: 978-1-60761-940-6
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