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Neural plasticity and proliferation in the generation of antidepressant effects: Hippocampal implication

AuthorsPilar-Cuéllar, Fuencisla CSIC ORCID; Vidal, Rebeca CSIC ORCID; Díaz, Álvaro CSIC ORCID; Castro, Elena CSIC ORCID; Anjos, Severiano dos CSIC; Pascual-Brazo, Jesús CSIC; Linge, Raquel CSIC; Vargas, Verónica Inés CSIC; Blanco, Helena CSIC; Martínez-Villayandre, Beatriz CSIC; Pazos, Ángel CSIC ORCID; Valdizán, Elsa M. CSIC ORCID
Issue Date2013
PublisherHindawi Publishing Corporation
CitationNeural Plasticity: 537265 (2013)
AbstractIt is widely accepted that changes underlying depression and antidepressant-like effects involve not only alterations in the levels of neurotransmitters as monoamines and their receptors in the brain, but also structural and functional changes far beyond. During the last two decades, emerging theories are providing new explanations about the neurobiology of depression and the mechanism of action of antidepressant strategies based on cellular changes at the CNS level. The neurotrophic/plasticity hypothesis of depression, proposed more than a decade ago, is now supported by multiple basic and clinical studies focused on the role of intracellular-signalling cascades that govern neural proliferation and plasticity. Herein, we review the state-of-the-art of the changes in these signalling pathways which appear to underlie both depressive disorders and antidepressant actions. We will especially focus on the hippocampal cellularity and plasticity modulation by serotonin, trophic factors as brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) through intracellular signalling pathways - cAMP, Wnt/β-catenin, and mTOR. Connecting the classic monoaminergic hypothesis with proliferation/neuroplasticity-related evidence is an appealing and comprehensive attempt for improving our knowledge about the neurobiological events leading to depression and associated to antidepressant therapies. © 2013 Fuencisla Pilar-Cuéllar et al.
DescriptionThis is an open access article distributed under the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1155/2013/537265
Identifiersdoi: 10.1155/2013/537265
issn: 2090-5904
e-issn: 1687-5443
Appears in Collections:(IBBTEC) Artículos
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