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Bioactivity of Bowman Birk Inhibitors in Themally processed orange juice

AuthorsCastillo, M. Dolores del ; Amigo-Benavent, Miryam; Bravo, Laura
Issue Date2011
CitationEuro Food Chem XVI (2011)
AbstractColon cancer is the second cause of death in Europe. Therefore, its prevention is crucial and functional foods may play a pivotal role on that. The most widely studied bioactive substances in soy are Bowman-Birk protease inhibitors (BBI protein) and the isoflavones. BBI is a serine protease inhibitor with a well-characterised ability to inhibit trypsin and chymotrypsin. Its chemoprotective effects have been well documented. Although the precise mechanisms by which BBI suppress carcinogenesis are unknown a strong correlation between its ability to inhibit carcinogenesis and its chymotrypsin inhibitor activity has been suggested. BBI’s potential to be used as chemo-preventive functional food ingredients has been proposed; however, there are not data related to resistance of BBI proteins to thermal treatment of low pH foods such as fruit juices. Research is needed to evaluate pure BBI as functional ingredient in complex food matrices. The objective of this research is to obtain new health enhancing phytochemicals (BBI) foods. Orange juice was freshly prepared and divided into aliquots. Citrate buffer 50 M pH 3.7 was employed as simplified orange juice model system. Both samples were supplemented with therapeutic dose of pure BBI (1.75 μM final concentration) and thermally treated under pasteurisation and sterilisation conditions. The concentration and chymotrypsin inhibitory activity of BBI in fresh, supplemented and heated samples were analysed. Data suggest that BBI remains active in the food matrix after both pasteurisation and sterilisation indicating the feasibility of its use as potential natural functional food ingredient.
DescriptionResumen del póster presentado a la XVI Conference EuroFoodChem: "Translating food chemistry into health benefits" celebrada en Gdansk (Polonia) del 6 al 8 de julio de 2011.
Appears in Collections:(ICTAN) Comunicaciones congresos
(CIAL) Comunicaciones congresos
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