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Title

Downregulation of tumor growth and invasion by redox-active nanoparticles

AuthorsAlili, Liruja; Sack, Maren; Montfort, Claudia von
Issue Date2013
PublisherMary Ann Liebert
CitationAntioxidants and Redox Signaling 19(8): 765-778 (2013)
Abstract[Aims]: Melanoma is the most aggressive type of malignant skin cancer derived from uncontrolled proliferation of melanocytes. Melanoma cells possess a high potential to metastasize, and the prognosis for advanced melanoma is rather poor due to its strong resistance to conventional chemotherapeutics. Nanomaterials are at the cutting edge of the rapidly developing area of nanomedicine. The potential of nanoparticles for use as carrier in cancer drug delivery is infinite with novel applications constantly being tested. The noncarrier use of cerium oxide nanoparticles (CNPs) is a novel and promising approach, as those particles per se show an anticancer activity via their oxygen vacancy-mediated chemical reactivity. [Results]: In this study, the question was addressed of whether the use of CNPs might be a valuable tool to counteract the invasive capacity and metastasis of melanoma cells in the future. Therefore, the effect of those nanoparticles on human melanoma cells was investigated in vitro and in vivo. Concentrations of polymer-coated CNPs being nontoxic for stromal cells showed a cytotoxic, proapoptotic, and anti-invasive capacity on melanoma cells. In vivo xenograft studies with immunodeficient nude mice showed a decrease of tumor weight and volume after treatment with CNPs. [Innovation]: In summary, the redox-active CNPs have selective pro-oxidative and antioxidative properties, and this study is the first to show that CNPs prevent tumor growth in vivo. [Conclusion]: The application of redox-active CNPs may form the basis of new paradigms in the treatment and prevention of cancers. Antioxid. Redox Signal. 19, 765-778. © 2013, Mary Ann Liebert, Inc.
DescriptionThis work is part of the PhD thesis of M.S. at the Heinrich-Heine-University of Düsseldorf.-- et al.
Publisher version (URL)http://dx.doi.org/10.1089/ars.2012.4831
URIhttp://hdl.handle.net/10261/88470
DOI10.1089/ars.2012.4831
Identifiersdoi: 10.1089/ars.2012.4831
issn: 1523-0864
e-issn: 1557-7716
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