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Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors

AuthorsMartínez, Ana ; Castro, Ana ; Gil, Carmen ; Miralpeix, Montserrat; Segarra, Víctor; Doménech, Teresa; Beleta, Jorge; Palacios, José M.; Ryder, Hamish; Miró, Xavier; Bonet-Costa, Carles ; Casacuberta, Josep M. ; Azorín, Ferran ; Piña, Benjamín ; Puigdomènech, Pere
Issue Date2000
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 43: 683- 689 (2000)
AbstractThe synthesis of a new family of benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]-thiadiazine 2,2-dioxides was achieved. The biological data revealed the first heterocyclic family of compounds with PDE 7 inhibitory properties appearing to be a new objective for the treatment of T-cell- dependent disorders. The IC50 values or percent inhibition values of the compounds against PDE 7 were calculated by testing them against human recombinant PDE 7 expressed in S. cerevisiae. In this expression system the only cyclic nucleotide hydrolyzing activity present in cell extracts corresponded to human PDE 7. Isoenzyme selectivity PDE 7 versus PDE 4 and PDE 3 was also measured. Considering simultaneously inhibition of the three different isoenzymes, monobenzyl derivatives 15 and 23 showed interesting PDE 7 potency (around 10 μM); although not statistically significant, a trend toward selectivity with respect to PDE 3 and PDE 4 was obtained. Benzothiadiazine 16, although less potent at PDE 7 (IC50 = 25 μM), also showed a trend of selectivity toward PDE 3 and PDE 4. These compounds are considered the best leads for further optimization.
Identifiersdoi: 10.1021/jm990382n
issn: 0022-2623
e-issn: 1520-4804
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