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Title

Antioxidant and Anti-proliferative Activities of Astaxanthin Extracted from the shell Waste of Deep-water Pink Shrimp (Parapenaeus longirostris).

AuthorsSila, Assaâd; Ayed-Ajmi, Y.; Sayari, N.; Nasri, M.; Martínez Álvarez, Óscar ; Bougatef, Ali
KeywordsParapenaeus longirostris
Astaxanthin
Antiproliferative activity
Antioxidant activity
Shrimp waste.
Issue Date2013
PublisherBentham Science Publishers
Citationthe natural products journal 3: 82- 89 (2013)
AbstractShrimp processing waste is the single largest industrial waste in Tunisia causing diverse environmental problems. Extraction of astaxanthin from the shell waste of the deep-water pink shrimp (Parapenaeus longirostris) was investigated. A hight astaxanthin yield was obtained using acetone (72.42 µg/g). Thin layer chromatographic separation of carotenoid extracts from P. longirostris yielded three distinct bands. The Rf values for the three bands were respectively 0.33, 0.60, 0.80 which corresponded to astaxanthin, astaxanthin monoester and astaxanthin diester. The antioxidant activities of astaxanthin at different concentrations were evaluated using various in vitro antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reducing power, β-carotene bleaching and DNA nicking assays. Interestingly, astaxanthin extract showed strong antioxidant activity. The radical scavenging activities and reducing powers of astaxanthin were close to and even better than those of the synthetic antioxidant BHA. The astaxanthin extract from shrimp shell waste exhibited high inhibition of β-carotene bleaching and also showed a well DNA protection against degradation by hydroxyl radicals. The anti-proliferative activity of the astaxanthin extract was also investigated. The inhibition concentration (CI50) of proliferation of tumor cells of human laryngeal carcinoma (Hep 2 cells) was 300 µg astaxanthin /ml.
URIhttp://hdl.handle.net/10261/88065
DOI10.2174/2210315511303020002
Identifiersdoi: 10.2174/2210315511303020002
issn: 2210-3155
Appears in Collections:(ICTAN) Artículos
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