Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/88062
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Calisto, Bárbara M. | - |
dc.contributor.author | Broto, Alícia | - |
dc.contributor.author | Martinelli, Luca | - |
dc.contributor.author | Querol, Luca | - |
dc.contributor.author | Piñol, Jaume | - |
dc.contributor.author | Fita, Ignacio | - |
dc.date.accessioned | 2013-12-03T09:54:06Z | - |
dc.date.available | 2013-12-03T09:54:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1111/j.1365-2958.2012.08200.x | - |
dc.identifier | issn: 0950-382X | - |
dc.identifier | e-issn: 1365-2958 | - |
dc.identifier.citation | Molecular Microbiology 86(2): 382-393 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/88062 | - |
dc.description.abstract | Mycoplasma genitalium is an emerging human pathogen with the smallest genome found among self-replicating organisms. M.genitalium presents a complex cytoskeleton with a differentiated protrusion known as the terminal organelle. This polar structure plays a central role in functions essential for the virulence of the microorganism, such as motility and cell-host adhesion. A well-conserved Enriched in Aromatic and Glycine Residues motif, the EAGR box, is present in many of the proteins found in the terminal organelle. We determined the crystal structure of the globular domain from M.genitalium MG200 that contains an EAGR box. This structural information is the first at near atomic resolution for the components of the terminal organelle. The structure revealed a dimer stabilized by a compact hydrophobic core that extends throughout the dimer interface. Monomers present a new fold that contains an accurate intra-subunit symmetry relating two conspicuous hairpins. Some features, such as the domain plasticity and the presence and organization of the intra- and inter-subunit symmetry axes, support a role for the EAGR box in protein-protein interactions. Genetic, biochemical and microcinematography analyses of MG200 variants lacking the EAGR box containing domain confirm the relevant and specific association of this domain with cell motility. © 2012 Blackwell Publishing Ltd. | - |
dc.description.sponsorship | Funded by: Ministerio de Ciencia e Innovación. Grant Numbers: BFU2009-09268, BIO2007-67904-C02-01, BFU2010-22209-C02-01. | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.rights | closedAccess | - |
dc.title | The EAGR box structure: a motif involved in mycoplasma motility | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1365-2958.2012.08200.x | - |
dc.date.updated | 2013-12-03T09:54:06Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
14
checked on 23-mar-2024
WEB OF SCIENCETM
Citations
15
checked on 28-feb-2024
Page view(s)
352
checked on 28-mar-2024
Download(s)
115
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.